Join us
如果你相信科学的力量, 加入澳门第一赌城在线娱乐，努力突破科学的界限，提供改变生活的药物.
Next generation therapeutics
创造下一代的治疗方法
We are constantly pushing the boundaries of science to deliver life-changing medicines which will have the greatest and swiftest impact on the diseases we are aiming to treat, prevent, modify and in the future, even cure. It is only by enhancing our understanding of disease biology and uncovering new ways of targeting the drivers of disease that we will create the next generation of therapeutics across our main therapy areas in Oncology, 心血管，肾脏和代谢, and Respiratory and Immunology.
We are already leveraging the rapid advancements in science and technology to create new therapeutics, such as cell-based therapy, antibody therapeutics, 以及基于核苷酸的疗法, 对于以前被认为很困难的疾病机制, if not impossible, to target.1 Additionally, 澳门第一赌城在线娱乐正致力于整合候选药物及其与靶标相互作用的知识, the pathophysiology of disease and the delivery system in order to design advanced delivery technologies.2 每一个新的见解和每一条新的信息都使澳门第一赌城在线娱乐更接近创造更好, 为患者提供更先进、更有效的治疗.
Partnering with collaborators across the world is helping our scientists pioneer new approaches to drug discovery. In fact, 30% 澳门第一赌城在线娱乐早期的管道现在包括新的药物模式，包括寡核苷酸, mRNA and Anticalin® proteins.
技术工具箱为澳门第一赌城在线娱乐的
next-generation pipeline
Selecting the right target with a strong link to the drivers of disease remains the most important decision we make in the drug discovery process. Once this target is selected, we now have a toolbox of traditional and innovative molecules which we can use to enable us to target the novel biology. 您可以在下面探索澳门第一赌城在线娱乐的模态工具箱.
Small molecules
Small molecules
We have a long history of discovering and developing orally delivered small molecule medicines by harnessing innovative approaches to drug design and delivery. Small molecules can be designed to engage biological targets by various modes of action and act both intracellularly and extracellularly. Their distribution can further be tailored to allow for systemic exposure with or without brain penetration. Click on the tiles below to read more about our research from traditional small molecules which have long been a cornerstone of our business, to ground-breaking, 新的小分子方法，如PROTACs和环硅酸锆.
Antibody therapeutics
Antibody therapeutics
抗体可以非常准确地靶向蛋白质，并且可以通过工程设计来提高特异性, potency and affinity. We are expanding the scope of our antibody engineering platforms and designing new and improved therapeutics such as bispecific antibodies and fragment antibodies with an aim of accessing difficult-to-reach therapeutic targets. Learn more about our research efforts to create the next generation of antibody-based therapeutics by clicking on the tiles below.
Peptide or protein therapeutics
Peptide or protein therapeutics
通过澳门第一赌城在线娱乐在蛋白质工程方面的长期专业知识, 澳门第一赌城在线娱乐正在推进传统和新型的蛋白质和肽疗法. 因为蛋白质是大分子, they are generally not cell permeable and have traditionally been restricted to extracellular targets and injectable administration routes. 多肽是一种较小的蛋白质疗法. 它们通常发育得很小, 细胞外目标的特异性和高选择性配体.
Through various collaborations, we are exploring the development of not only traditional protein therapeutics and peptides but also potentially innovative therapies such as Anticalin® proteins and bicyclic peptides. 点击下面的图片阅读更多关于这些新型药物模式的信息.
Nucleotide-based therapeutics & gene therapy
Nucleotide-based therapeutics & gene therapy
基因组学的最新进展已经带来了无数潜在的新药物靶点, 基于核苷酸的治疗方法有机会对疾病产生真正的影响. We are exploring a number of nucleotide-based modalities from oligonucleotides and RNA-based therapies to using CRISPR/Cas9 as a potential therapeutic tool. 点击下面的图片阅读更多关于这些新型药物模式的信息.
来看看澳门第一赌城在线娱乐新一代疗法的先驱们
澳门第一赌城在线娱乐取得的每一项进步背后，都有一群敬业的科学家. 了解更多澳门在线赌城娱乐在药物发现前沿工作的研究人员的信息:
References
1. Valeur E, Guéret SM, Adihou H et al. 药物发现中挑战靶点的新模式. Angewandte Chemie. 2017. 56(35): 10294-10323.
2. Ashford M. Drug Deliv Transl Res. 2020 Oct 6. doi: 10.1007/s13346-020-00858-6. Online ahead of print.
Collaborate with us
澳门第一赌城在线娱乐知道，无论澳门第一赌城在线娱乐的科学多么创新, 无论澳门第一赌城在线娱乐的药物和递送多么有效, 实现澳门第一赌城在线娱乐想要实现的一切, we cannot do it alone.
Veeva ID: Z4-58111
筹备日期:2023年9月